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SciLifeLab seminar series-Campus Solna, Mark McCarthy, Genetic Signals Influencing Diabetes

Mark McCarthy is the Robert Turner Professor of Diabetes Medicine at the University of Oxford based at both Oxford Centre for Diabetes, Endocrinology and Metabolism and the Wellcome Centre for Human Genetics. His research group is focused on the identification and characterisation of genetic variants influencing risk of type 2 diabetes and related traits, and on using those discoveries to drive biological inference and translational opportunities.

He will talk about: “Now we have found over 400 genetic signals influencing type 2 diabetes, what on earth are we going to do with them?”

Tid: Ti 2018-09-18 kl 10.00 - 11.00

Plats: SciLifeLab Solna- Auditorium Air and Fire, Tomtebodavägen 23A, 17165 Solna, Sweden

Individual risk of common complex diseases such as type 2 diabetes is influenced by the impact of variation at many hundreds of loci, in combination with a wide range of exposures experienced over an individual’s life course. A deeper understanding of these factors, and the mechanisms through which they influence disease risk and development, is a prerequisite if we are to develop more effective strategies for prevention and treatment. My group leads efforts to find these genetic signals (over 450 now known), to fine-map the causal variants, and to define the genes and pathways through which they act, either directly in the case of coding variants, or indirectly for those with regulatory effects. This mechanistic view of T2D pathophysiology provides a framework for thinking about risk stratification, target validation and biomarker discovery.

Webpage for more information



Alice Sollazzo

E-mail thesvedberg@scilifelab.uu.se