AIMES - Crossing Borders with Anna Herland
Welcome to a hybrid seminar with Anna Herland, KTH Royal Institute of Technology & Karolinska Institutet
Time: Wed 2024-03-20 14.00 - 15.00
Location: Via Zoom or at Karolinska Institutet, Biomedicum, Solnavägen 9, Solna, room Peter Reichard, entrance
Title
”Engineering cellular interfaces in Organ-on-Chips”
Short abstract
Engineered human microfluidic Organ-on-Chip models are a promising pre-clinical technology for studies of specific cellular mechanisms and drug responses in physiological environments. In Organ-on-Chips, cells are cultured in interfacing microcompartments with perfusion. In our group, we are developing these systems from three perspectives: first, to increase human physiological relevance through stem cell engineering and a defined three-dimensional microenvironment; second, to incorporate non-disruptive real-time monitoring of cells; and third, to make them user-friendly and cost-effective. This talk will cover the developed and validated protocols to generate vascular and neural cells from human pluripotent stem cells for our NVU-on-Chip models. Our specific aim with these systems is to better understand metabolic interactions and disturbances in the neurovascular unit, which we have previously studied in human primary cells.
Full abstract and registration
For more information
AIMES - Center for the Advancement of Integrated Medical and Engineering Sciences (aimes.se)