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Electroanalytical Platforms Based on Textiles and Printed Circuit Boards for Point-of-Need Tests

Time: Fri 2024-10-25 14.00

Location: Kollegiesalen, Brinellvägen 8, Stockholm

Language: English

Subject area: Fibre and Polymer Science

Doctoral student: Martin Hanze , Fiberprocesser

Opponent: Biträdande universitetslektor Onur Parlak, Karolinska Institutet

Supervisor: Professor Mahiar Hamedi, Fiberprocesser; Docent Erica Zeglio, Stockholms universitet; Doktor Anna Toldrà Filella, Karolinska Institutet

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QC 20241003

Abstract

Point-of-need devices perform analytical tests that help inform decisions where they are needed, away from modern lab infrastructure, be it in-field or in resource-poor settings. They have many applications, including veterinary medicine, agriculture, food safety, environmental monitoring, and forensics. In medical diagnostics, such devices are called point-of-care tests, and they could help combat societal challenges such as the spread of epidemic diseases and providing adequate healthcare in developing countries. Point-of-care devices could also be wearable to non-invasively monitor body fluids such as sweat or urine from the patient. Ideal point-of-care devices conform with the REASSURED criteria, that they should be Real-time connected, Easy to collect samples, Affordable, Sensitive, Specific, User-friendly, Rapid, robust, Equipment-free, environmentally friendly, and Deliverable to the end user.

We have here developed Point-of-need devices based on textiles and Printed Circuit Boards (PCBs); both well-established technologies that could offer low-cost mass production using existing industrial resources. Specifically, we have made electrochemical biosensors based on gold-coated yarn in a rolling architecture, as well as combined with wicking Coolmax® yarn acting as microfluidic channels in wearable systems, enabling advanced textile-based diagnostic devices suitable for automation or machine-stitching into fabrics. We also showed biosensors based on gold-coated PCBs that can connect to portable potentiostats for electrochemical detection and have integrated heating for isothermal nucleic acid amplification.

urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-354239